Enriched environment and Mash1 transfection affect neural stem cell differentiation after transplantation into the adult somatosensory cortex

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• 作者：Mitsunori D. Arai^a ; Bo Zhan^a ; Atsuko Maruyama^a ; Akiko Matsui-Harada^a ; Kazuhiro Horinouchi^a ; Shoji Komai^a ; ^b ; ^{skomai@bs.naist.jp}
• 关键词：ACSF ; artificial cerebrospinal fluid ; bFGF ; basic fibroblast growth factor ; bHLH ; basic helix-loop-helix ; DMEM ; Dulbecco's modified Eagle medium ; EE ; enriched environment ; EPSC ; excitatory postsynaptic currents ; GABA ; gamma-aminobutyric acid ; GAD ; glutamic acid decarboxylase ; GFAP ; glial fibrillary acidic protein ; HSD ; honest significant difference ; Mash1 ; achaete-scute homolog 1 ; NeuN ; neuronal nuclear antigen ; Ngn2 ; neurogenin 2 ; NSC ; neural stem cell ; PSC ; primary somatosensory cortex
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：373
• 期：Complete
• 页码：73-80
• 全文大小：1576 K
• 卷排序：373

文摘

Enriched environment enhanced NSC differentiation into NeuN-positive neurons. Mash1-transduced NSCs resulted in an increased GAD-negative neuron population. Enriched environment promoted recovery after neurorehabilitative cell transplant.