Ginsenoside Rb1 Attenuates Acute Inflammatory Nociception by Inhibition of Neuronal ERK Phosphorylation by Regulation of the Nrf2 and NF-κB Pathways
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- 作者：Minhee Jang&lowast ; ; &dagger ; ; Min Jung Lee&lowast ; ; &Dagger ; ; Jong Hee Choi&lowast ; ; &Dagger ; ; Eun-Jeong Kim&lowast ; ; &Dagger ; ; Seung-Yeol Nah§ ; ; Hak-Jae Kim¶ ; ; Sanghyun Lee|| ; Sang Won Lee&lowast ; &lowast ; ; Young Ock Kim&lowast ; &lowast ; ; Ik-Hyun Cho&lowast ; ; &Dagger ; ; &dagger ; &dagger ; ; ihcho@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ginsenoside-Rb1 ; intrathecal introduction ; inflammatory nociception ; phospho-ERK ; nuclear factor erythroid 2-related factor 2 ; nuclear factor-kappa B
- 刊名：The Journal of Pain
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：17
- 期：3
- 页码：282-297
- 全文大小：4175 K
文摘
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Intrathecal introduction of ginsenoside-Rb1 (Rb1) decreased nociceptive behavior.
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Rb1 decreased activation of the proto-oncogene c-Fos in the spinal dorsal horn.
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Rb1 inhibited neuronal extracellular signal-regulated kinase phosphorylation.
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Rb1 activated the nuclear factor erythroid 2-related factor 2 pathway.
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Rb1 inhibited the nuclear factor kappa B pathway.