Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression

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• 作者：Tanveer Singh ; Rajesh Kumar Goel ; ^{goelrkpup@gmail.com}
• 关键词：7-Nitroindazole ; Corticosterone ; Depression ; Epilepsy ; Nitric oxide ; Pentylenetetrazole
• 刊名：Pharmacological Reports
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：69
• 期：1
• 页码：143-149
• 全文大小：1270 K
• 卷排序：69

文摘

The study was envisaged to explore the adjuvant nNOS inhibition with valproate for combined treatment epilepsy and comorbid depression. Neurochemical changes suggest elevated nitrosative may be responsible for depression associated with epilepsy. Valproate treatment in kindled animals decreased seizure severity, but was found unable to curb elevated nitrosative stress. Adjuvant 7-nitroindazole (selective nNOS inhibitor) with valproate ameliorated both epilepsy and associated depression.