Chemokine regulation of neutrophil function in tumors
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- 作者：Ornella Bonavitaa ; b ; 1Author Vitae ; Matteo Massaraa ; b ; 1Author Vitae ; Raffaella Bonecchia ; c ; raffaella.bonecchi@humanitasresearch.it" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：PMNs ; polymorphonuclear leukocytes ; TANs ; Tumor associated neutrophils ; N1 ; proinflammatory ; N2 ; anti-inflammatory tumor-promoting neutrophils ; ELA2 ; neutrophil elastase ; MMP8 ; neutrophils collagenase ; MMP9 ; neutrophils gelatinase B ; ECM ; extracellular matrix ; RNS ; reactive nitrogen species ; ROS ; reactive oxygen species ; HGF ; hepatocyte growth factor ; PGE2 ; prostaglandin E2 ; NETs ; neutrophil extracellular traps ; PD-L1 ; programmed death-ligand 1 ; TRAIL ; TNF-related apoptosis-inducing ligand ; ICAM
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：81-86
- 全文大小：676 K
文摘
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Neutrophils are endowed with both pro- and antitumor functions.
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Circulating neutrophils are a heterogeneous population.
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Anti-tumoral (N1) neutrophils are present in early stages of tumors and metastasis while in later stages pro-tumoral (N2) neutrophils predominate.
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CXC chemokines binding CXCR1 and CXCR2 are abundantly produced by tumors to recruit neutrophils.
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After extravasation neutrophils acquire a new pattern of chemokine receptors including CCR2 that promote anti-tumoral activity.