Fatty acid amide hydrolase (FAAH) blockade ameliorates experimental colitis by altering microRNA expression and suppressing inflammation

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• 作者：Haidar Shamran^a ; Narendra P. Singh^a ; Elizabeth E. Zumbrun^a ; Angela Murphy^a ; Dennis D. Taub^b ; Manoj K. Mishra^c ; Robert L. Price^d ; Saurabh Chatterjee^e ; Mitzi Nagarkatti^a ; Prakash S. Nagarkatti^a ; Udai P. Singh^a ; ^{udai.singh@uscmed.sc.edu}
• 关键词：FAAH ; Fatty acid amide hydrolase ; DSS ; Dextran sodium sulphate ; MLN ; Mesenteric lymph nodes ; PPs ; Peyer&rsquo ; s patches ; CB1-2 ; Cannabinoid receptors 1&ndash ; 2 ; AEA ; Anandamide ; TNF-α ; Tumor Necrosis Factor-Alpha ; IBD ; Inflammatory Bowel Disease ; UC ; Ulcerative Colitis ; CD ; Crohn&rsquo ; s Disease ; TNBS ; Trinitrobenzene sulfonic acid ; miRNAs ; MicroRNAs
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：10-20
• 全文大小：2240 K
• 卷排序：59

文摘

Fatty acid amide hydrolase (FAAH) involved in the modulation of intestinal physiology. FAAH-II improved clinical scores reversing weight loss and colitis-associated pathogenesis. FAAH-II reducing the frequency of activated T cells, macrophages, neutrophils, and NK/NKT cells in the colon. FAAH-II mediates inflammatory cytokine and miRNAs at mucosal sites.