Pharmacogenetics of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in resource-limited settings: Influence on antiretroviral therapy response and concomitant anti-tubercular, antimalarial and contraceptive treatments
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- 作者：Gianluca Russoa ; Giacomo Maria Paganottib ; c ; paganottig@botswana-upenn.co.bw" class="auth_mail" title="E-mail the corresponding author ; Sandra Soeria-Atmadjad ; Miriam Haverkampb ; Doreen Ramogola-Masireb ; Vincenzo Vulloa ; Lars Lennart Gustafssone
- 关键词：Drug&ndash ; drug interactions ; Efavirenz ; HIV ; Nevirapine ; Pharmacogenetics ; Resource-limited countries
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：37
- 期：Complete
- 页码：192-207
- 全文大小：690 K
文摘
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The burden of the HIV infection is mainly concentrated in resource-limited countries.
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There, anti-HIV therapy is based on efavirenz- or nevirapine-combination therapies.
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The variability of drugs' pharmacokinetics is driven by different genetic backgrounds.
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Another cause of pharmacokinetic's variation is drug–drug interaction.
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We explore pharmacogenetic interactions among HIV, TB and antimalarial drugs.