Antiangiogenetic effects of anthranoids from Alternaria sp., an endophytic fungus in a Thai medicinal plant Erythrina variegata

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• 作者：Phunlap Pompeng ; Damrong Sommit ; Nongluksna Sriubolmas ; Nattaya Ngamrojanavanich ; Kiminori Matsubara ; Khanitha Pudhom
• 关键词：Anthranoid ; Antiangiogenesis ; Endophytic fungus ; Alternaria species ; Erythrina variegata
• 刊名：Phytomedicine
• 出版年：2013
• 出版时间：15 July, 2013
• 年：2013
• 卷：20
• 期：10
• 页码：918-922
• 全文大小：761 K

文摘

Endophytic fungi are known as a prolific source for the discovery of structurally interesting and biologically active secondary metabolites, some of which are promising candidates for drug development. In the present study, three anthranoids were isolated from an Alternaria sp. endophytic fungus and evaluated for their antiangiogenic activity in a rat aortic sprouting assay, an ex vivo model of angiogenesis. Of these three compounds, altersolanol (2) was further characterized and found to show a promising activity in ex vivo, in vitro and in vivo angiogenesis asssays. Using human umbilical vein endothelial cells as an in vitro model, the angiogenic effect of 2 was found to occur via suppression of all three main functions of endothelial cells, namely proliferation, tube formation and migration.