Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin
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- 作者：Hongli Chena ; chenhlhl@126.com" class="auth_mail" title="E-mail the corresponding author ; Li Qin Xiea ; Jingwen Qina ; Yajing Jiaa ; Xinhua Caib ; WenBin Nana ; Wancai Yangb ; wyang06@uic.edu" class="auth_mail" title="E-mail the corresponding author ; Feng Lvc ; Qi Qing Zhangc
- 关键词：PLGA nanoparticle ; Chitosan ; Biotin ; Epbrubicin
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：1-9
- 全文大小：2468 K
文摘
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We successfully prepared Bio-CS-PLGA NPs with active functional group of biotin on their surface.
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Bio-CS-PLGA NPs exhibited a greater extent of cellular uptake.
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Bio-CS-PLGA NPs were able to enter into cancer cells via biotin receptor endocytosis.
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Bio-CS-PLGA NPs were mainly distributed in the tumor after 24 h post administration.