Future directions for resuscitation research. IV. Innovative advanced life support pharmacology
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- 作者：Brown ; Charles ; Wiklund ; Lars ; Bar-Joseph ; Gad ; Miller ; Brian ; Bircher ; Nicholas ; Paradis ; Norman ; et. al.
- 关键词：Adrenergic agonists ; Anti-arrhythmia agents ; Buffers ; Cardiopulmonary resuscitation ; Clinical trials ; Defibrillation ; Electric countershock ; Electrocardiography ; Intraosseous medication ; Ventricular fibrillation
- 刊名：Resuscitation
- 出版年：1996
- 出版时间：December, 1996
- 年：1996
- 卷：33
- 期：2
- 页码：163-177
- 全文大小：1.67 M
文摘
The topics discussed in this session include a partial review of laboratory and clinical studies examining the effects of adrenergic agonists on restoration of spontaneous circulation after cardiac arrest, the effects of varying doses of epinephrine, and the effects of novel vasopressors, buffer agents (NaHCO3, THAM, ‘Carbicarb’) and anti-arrhythmics (lidocaine, bretylium, amiodarone) in refractory ventricular fibrillation. Novel therapeutic approaches include titrating electric countershocks against electrocardiographic power spectra and of preceding the first countershocks with single or multiple drug treatments. These approaches need to be investigated further in controlled animal and patient studies. Epidemiologic data from randomized clinical outcome studies can give clues, but cannot document pharmacologic mechanisms in the dynamically changing events during attempts to achieve restoration of spontaneous circulation from prolonged cardiac arrest. Also, rapid drug administration by the intraosseous route was compared with intratracheal and intravenous (i.v.) drug administration.