The Microbiome in Necrotizing Enterocolitis: A Case Report in Twins and Minireview

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• 作者：Suchitra K. Hourigan ; MD¹ ; ² ; ³ ; ⁴ ; ^⁎ ; ^{suchihourigan@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Allison Ta ; MD² ; ^⁎ ; Wendy S.W. Wong ; PhD¹ ; Nicole C. Clemency ; BSc¹ ; Marina G. Provenzano ; BSc¹ ; Rajiv Baveja ; MD¹ ; Ramaswamy Iyer ; PhD¹ ; Elisabeth Klein ; RN¹ ; John E. Niederhuber ; MD¹ ; ⁴
• 关键词：intestinal microbiome ; necrotizing enterocolitis ; twins ; neonate
• 刊名：Clinical Therapeutics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：38
• 期：4
• 页码：747-753
• 全文大小：275 K

文摘

Our case describes the serial microbiome changes in twins discordant for necrotizing enterocolitis (NEC), who shared similar intrauterine and early environmental exposures. The key findings were that the 2 neonates had distinctly different microbiome compositions from the first stool samples collected. Also, in the twin who developed NEC there was a decrease in bacterial diversity and an increase in Proteobacteria a week before developing any clinical symptoms, suggesting an early role of the intestinal microbiome in the development of NEC. Here we briefly review the literature on the role of the intestinal microbiome in NEC and how a greater understanding of the neonatal microbiome and host interactions may help mitigate this devastating disease.