9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease

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• 作者：LA Massey^a ; ^b ; ^{lukemassey@doctors.net.uk} ; MA Miranda^c ; O Al-Helli^a ; ^e ; HG Parkes^e ; JS Thornton^f ; P-W So^g ; MJ White^f ; L Mancini^f ; C Strand^b ; J Holton^b ; AJ Lees^a ; ^b ; ^d ; T Revesz^b ; TA Yousry^e ; ^f
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：154-163
• 全文大小：1621 K
• 卷排序：13

文摘

We demonstrate the substantia nigra anatomy using high field spin-echo MRI. MRI - pathological correlation validates our findings. We were able to delineate the subcompartments of the substantia nigra - the nigrosomes. In Parkinson's disease nigrosome structure was maintained but it was lost in progressive supranuclear palsy.