Characterization of a reproducible rat EAMG model induced with various human acetylcholine receptor domains

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• 作者：Konstantinos Lazaridis^a ; ^{klazaridis@pasteur.gr} ; Vassiliki Baltatzidi^a ; Nikolaos Trakas^a ; Eleni Koutroumpi^a ; Nikolaos Karandreas^b ; Socrates J. Tzartos^a ; ^c ; ^{tzartos@pasteur.gr}
• 关键词：MG ; myasthenia gravis ; AChR ; nicotinic acetylcholine receptor ; ECD ; extracellular domain ; MIR ; main immunogenic region ; AChBP ; acetylcholine binding protein ; α-Btx ; α-bungarotoxin ; EAMG ; experimental autoimmune myasthenia gravis ; EMG ; electromyography
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：303
• 期：Complete
• 页码：13-21
• 全文大小：1201 K
• 卷排序：303

文摘

We successfully induced experimental MG in rats with domains of each of the h-AChR subunits. This is the first demonstration of EAMG with the non-α human AChR subunits. The α subunit ECD was more pathogenic than the non-α subunits. Immunization with a combination of subunits was more pathogenic than each one individually.