The role of mhc polymorphism in anti-microbial resistance
详细信息 查看全文
- 作者：Nikolich-Zugich ; Janko ; Fremont ; Daved H. ; Miley ; Michael J. ; Messaoudi ; Ilhem
- 关键词：MHC ; T-cell receptor ; Immunity ; Pathogen resistance ; bm ; mhc mutation arising in the murine H-2b haplotype ; CDR regions ; complementarity-determining region of the TCR ; CTL ; cytotoxic T lymphocytes ; dm ; mhc mutation arising in the murine H-2
- 刊名：Microbes and Infection
- 出版年：2004
- 出版时间：April, 2004
- 年：2004
- 卷：6
- 期：5
- 页码：501-512
- 全文大小：468 K
文摘
The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.