Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin
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- 作者：Brice E. Keyes1 ; 2 ; 3 ; Siqi Liu1 ; 2 ; Amma Asare1 ; Shruti Naik1 ; John Levorse1 ; Lisa Polak1 ; Catherine P. Lu1 ; Maria Nikolova1 ; Hilda Amalia Pasolli1 ; 4 ; Elaine Fuchs1 ; 5 ; fuchslb@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aging ; wound healing ; re-epithelialization ; Skint ; DETC ; epidermal-immune cell cross-talk ; STAT3
- 刊名：Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：167
- 期：5
- 页码：1323-1338.e14
- 全文大小：9704 K
文摘
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Intrinsic and extrinsic defects impair wound re-epithelialization in aged skin
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Loss of DETCs at the wound edge delays wound repair in aged skin
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Epidermally expressed Skint3/9 mediate keratinocyte-DETC cross-talk
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IL6/STAT3 signaling regulates Skint expression and facilitates proper wound healing