Plasma kallikrein-bradykinin pathway promotes circulatory nitric oxide metabolite availability during hypoxia
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- 作者：Gayatri Padhy ; Anamika Gangwar ; Manish Sharma ; Gidugu Himashree1 ; Krishan Singh2 ; Gopinath Bhaumik ; Kalpana Bhargava ; kalpanab2006@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Niroj Kumar Sethy ; nksethy@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nitric oxide ; Plasma kallikrein ; Bradykinin ; Hypoxia ; High altitude
- 刊名：Nitric Oxide
- 出版年：2016
- 出版时间：1 May-1 June 2016
- 年：2016
- 卷：55-56
- 期：Complete
- 页码：36-44
- 全文大小：1284 K
文摘
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Plasma proteomes of Ladakhi natives along with high altitude sojourners (post 1, 4, 7 days) were studied.
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Kininogen – plasma kallikrein – bradykinin pathway was identified for regulating eNOS activity in both groups.
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Plasma biomarkers for NO production were elevated in both groups and more significant in Ladakhi natives.
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Ladakhi natives also possessed significant lower levels of oxidative stress as compared to high altitude sojourners.