Two pairs of farnesyl phenolic enantiomers as natural nitric oxide inhibitors from Ganoderma sinense

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• 作者：Meng Wang^a ; Fei Wang^a ; Feng Xu^a ; Li-Qin Ding^b ; Qian Zhang^c ; Hui-Xiang Li^c ; Feng Zhao^c ; Li-Qing Wang^a ; Li-Han Zhu^a ; Li-Xia Chen^a ; ^{syzyclx@163.com" class="auth_mail" title="E-mail the corresponding author} ; Feng Qiu^a ; ^b ; ^{fengqiu20070118@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ganoderma sinense ; Farnesyl phenol ; NO inhibitory activity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 July 2016
• 年：2016
• 卷：26
• 期：14
• 页码：3342-3345
• 全文大小：583 K

文摘

Four new farnesyl phenolic compounds, ganosinensols A–D (1–4) were isolated from the 95% EtOH extract of the fruiting bodies of Ganoderma sinense. Two pairs of enantiomers, 1/2, and 3/4 were isolated by HPLC using a Daicel Chiralpak IE column. Their structures were elucidated from extensive spectroscopic analyses and comparison with literature data. The absolute configurations of 1–4 were assigned by ECD spectra. All of these isolated compounds showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, with IC₅₀ values from 1.15 to 2.26 μM.