Local and systemic vasodilatory effects of low molecular weight S-nitrosothiols
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- 作者：Taiming Liua ; Hobe J. Schroederb ; Sean M. Wilsonb ; Michael H. Terryc ; Monica Romerod ; Lawrence D. Longob ; Gordon G. Powerb ; Arlin B. Blooda ; b ; ablood@llu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：SNOs ; S-nitrosothiols ; L-cysNO ; S-nitroso-L-cysteine ; GSNO ; S-nitroso-glutathione ; NO ; nitric oxide ; sGC ; soluble guanylate cyclase ; MAP ; mean arterial blood pressure ; DTPA ; diethylene triamine pentaacetic acid ; HSNO ; thionitrous acid ; PDI ; protein disulfide isomerase
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：215-223
- 全文大小：1311 K
文摘
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SNOs were infused intra-arterially while measuring local and systemic vasodilation.
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L-cysNO caused local dilation, but D-cysNO and GSNO did not.
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Despite varying membrane permeabilities, all three SNOs caused systemic vasodilation.
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SNOs dilated the sheep mesenteric vasculature more potently than that of the hindlimb.
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Hemodynamic effects of SNOs depend on an S-transnitrosylation equilibrium in blood.