Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients

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• 作者：Jing Zhang ; Yifeng Shen ; Guang He ; Xingwang Li ; Junwei Meng ; Shengzhen Guo ; Huafang Li ; Niufan Gu ; Guoyin Feng ; Lin He
• 关键词：5HTT ; Association ; HTR2A ; HTR2C ; Suicidal behavior
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2008
• 出版时间：15 February 2008
• 年：2008
• 卷：32
• 期：2
• 页码：467-471
• 全文大小：134 K

文摘

Suicide is a significant health problem throughout the world. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors (HTR2A, HTR2C) and one serotonin transporter (5HTT) in suicide victims. Rs6313 (T102C) of HTR2A and rs6318 (Cys23Ser) of HTR2C have been investigated in suicide behavior in other studies.

Methods

Here, we investigated rs6313 and rs6318 and other 10 randomly chosen SNPs, of those three genes in a study of 329 psychiatric patients who had never attempted suicide and 297 patients who had attempted suicide.

Results

No associations were found for the 12 SNPS.

Conclusions

Our results do not support the involvement of HTR2A, 5HTT or HTR2C in suicidal behavior in Han Chinese subjects.