Human bronchial epithelial cells injury and cytokine production induced by Tityus serrulatus scorpion venom: An in vitro study
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- 作者：Vera Lucia Silva Rigonia ; Fabio H. Kwasniewskib ; Rodolfo Paula Vieiraa ; Ingrid Sestrem Linharesa ; Joelmir Lucena Veiga da Silvac ; Amanda Nogueira-Pedrod ; Stella Regina Zamunera ; stella.rz@uni9.pro.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tityus serrulatus venom ; Bronchial epithelial cell ; Citotoxicity ; Necrosis ; Cytokines
- 刊名：Toxicon
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：22-28
- 全文大小：989 K
文摘
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Effect of Tityus serrulatus venom (Tsv) on human bronchial epithelial cells (BEAS-2B).
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Tsv caused a decrease in cell viability at 10 and 50 μg/mL.
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Necrosis is the main cell death pathway caused by Tsv in BEAS-2B cells.
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Tsv activates BEAS-2B cells to produce cytokines IL-1β, IL-6 and IL-8.