Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis

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• 作者：Abdel-Hadi Al-Ja’ ; fari^a ; ^c ; Roser Vila^a ; Blanca Freixa^a ; Felix Tomi^b ; Joseph Casanova^b ; Joan Costa^c ; Salvador Cañ ; igueral^a ; ^{s.canigueral@ub.edu"" rel=""nofollow}
• 关键词：Ferula hermonis ; Essential oil ; α ; -Pinene ; 3 ; 5-Nonadiyne ; Jaeschkeanadiol benzoate ; Antifungal activity ; Dermatophytes
• 刊名：Phytochemistry
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：72
• 期：11-12
• 页码：1406-1413
• 全文大小：275 K

文摘

The analysis of the essential oil from rhizome and roots of Ferula hermonis Boiss. (Apiaceae) by GC–FID, GC–MS and ¹³C NMR allowed the identification of 79 constituents, more than 90 % of the oil, the major one being α-pinene (43.3 % ), followed by α-bisabolol (11.1 % ) and the unusual acetylenic compound 3,5-nonadiyne (4.4 % ).

The antifungal activity of the essential oil before and after fractionation was assayed against several yeasts and filamentous fungi. Purification of the active fractions afforded 3,5-nonadiyne, α-bisabolol, jaeschkeanadiol angelate, α-bisabolol oxide B and trans-verbenol, as well as two purified fractions, one of them (JB73) with 73 % of jaeschkeanadiol benzoate and the other with 50 % of spathulenol. Determination of MIC and MFC values of all these products evidenced strong antifungal activities for JB73 and 3,5-nonadiyne. Particularly, against the dermatophyte Tricophyton mentagrophytes, MIC and MFC values were 0.25 μg/ml for JB73, and 8 μg/ml for 3,5-nonadiyne, the former being more active than amphotericin B and nystatin.