Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs
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- 作者：Maria V. Yelshanskaya1 ; Appu K. Singh1 ; Jared M. Sampson1 ; Chamali Narangoda2 ; Maria Kurnikova2 ; Alexander I. Sobolevsky1 ; 3 ; as4005@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：21 September 2016
- 年：2016
- 卷：91
- 期：6
- 页码：1305-1315
- 全文大小：4864 K
文摘
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Crystal structures reveal binding of antiepileptic drugs to AMPA receptors
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Binding occurs at a novel allosteric site on the ion channel extracellular side
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The drugs are noncompetitive inhibitors acting as wedges to prevent channel opening
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Binding site molecular composition provides a template for synthesis of new drugs