CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation
详细信息 查看全文
- 作者：Christian Grant ; Michael Nonnemacher ; Pooja Jain ; Devanshi Pandya ; Bryan Irish ; Simon C. Williams and Brian Wigdahl
- 关键词：HTLV-1 ; Tax ; CCAAT/enhancer-binding protein ; Long terminal repeat ; HAM/TSP ; Monocyte– ; macrophage
- 刊名：Virology
- 出版年：2006
- 出版时间：10 May 2006
- 年：2006
- 卷：348
- 期：2
- 页码：354-369
- 全文大小：1074 K
文摘
CCAAT/enhancer-binding protein (C/EBP) basic region/leucine zipper (bZIP) transcription factors have been shown to form heterodimers with cAMP-responsive element binding protein 2 (CREB-2), a transcription factor involved in regulating basal and Tax-mediated transactivation of the human T cell leukemia virus type 1 (HTLV-1) long terminal repeat (LTR). In cells of the monocyte–macrophage lineage (proposed to play a role in HTLV-1 pathogenesis as an accessory target cell), several members of the C/EBP family are expressed at high levels and may have functional impact on both basal and Tax-mediated transactivation of the HTLV-1 LTR. Basal activation of the HTLV-1 LTR was enhanced by overexpression of C/EBPβ, C/EBPδ, or C/EBPε, whereas transactivation of the LTR by Tax was inhibited by overexpression of C/EBPα and C/EBPβ. Inhibition of Tax-mediated transactivation of the HTLV-1 LTR was co-activator-independent, did not require C/EBP binding to the Tax-responsive elements, and may involve heterodimerization with CREB factors.