Detection of Helicobacter pylori in children and adolescents using the monoclonal coproantigen immunoassay and its association with gastrointestinal diseases

详细信息    查看全文

• 作者：Veró ; nica Castillo-Montoya^a ; Eduardo Ruiz-Bustos^b ; Mauro Eduardo Valencia-Juillerat^c ; Gerardo Á ; lvarez-Herná ; ndez^c ; Norberto Sotelo-Cruz^c ; ^{norberto.sotelo@unison.mx} ; ^{norbertosotelo5@hotmail.com}
• 关键词：Helicobacter pylori ; Infection in children ; Diagnosis ; Monoclonal coproantigen
• 刊名：Cirugía y Cirujanos (English Edition)
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：85
• 期：1
• 页码：27-33
• 全文大小：387 K
• 卷排序：85

文摘

Infection by Helicobacter pylori (H. pylori) affects 50% of the world population. Simple methods for its detection are now available.ObjectivesTo identify H. pylori by using a monoclonal coproantigen technique in paediatric patients, and to determine its association with gastrointestinal diseases.Materials and methodsThe study included a total of 110 subjects aged 1 to 18 years. The study variables included: Family history of gastrointestinal disease, age, gender, gastrointestinal symptoms, as well as apparently healthy (asymptomatic) subjects. The monoclonal coproantigen test was performed on stool samples. Two groups, I symptomatic (n = 29), and II asymptomatic (n = 81) were compared using parametric and non-parametric statistics.ResultsOf the 110 patients, 59 (54%) were male. The relationship between a family history of gastritis and a positive for H. pylori, was significant for mothers (p < 0.0005), fathers (p < 0.0001), and paternal grandfathers (p < 0.0001). It was significant for gastric cancer in maternal grandparents (p < 0.0178) and paternal grandparents (p < 0.0092). The monoclonal coproantigen test was positive in 31 (28.2%) of the subjects. All were positive in group I, and only 2 in group II. A significant positive association was observed between H. pylori and various signs and symptoms, such as epigastric pain (p < 0.001), recurrent peri-umbilical pain (p < 0.001), bloating (p = 0.016), heartburn (p = 0.0007), nausea (p = 0.0061), diarrhoea (p = 0.0389), and constipation (p = 0.0019).ConclusionsH. pylori detection, was positive in 28% of both groups, and showed significant relationships with family gastrointestinal diseases and gastrointestinal symptoms.