Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer

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• 作者：Sarah Knockep>1p> ; Bettina Fleischmann-Mundtp>1p> ; Michael Saborowskip>1p> ; Michael P. Mannsp>1p> ; Florian K&uuml ; hnelp>1p> ; Thomas C. Wirthp>1p> ; Norman Wollerp>1p>p> ; p>p>2p>p> ; p>p>woller.norman@mh-hannover.dep>
• 关键词：oncogenic ras ; CD8 T cells ; CD4 T cells ; cancer immunosurveillance ; neoepitopes ; immunoediting ; T cell regulation ; immune responses to cancer ; cancer mouse model ; senescence surveillance
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2234-2246
• 全文大小：4360 K
• 卷排序：17

文摘

We develop a liver cancer mouse model to investigate the CD4 and CD8 T cell crosstalk Tumor-specific CD8 T cell responses arise independently of CD4 T cells MHC class I immunogenicity is essential to trigger tumor-directed CD4 T cell responses Epitopes from immunoedited tumors lack responsiveness for cancer immunosurveillance