Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancer
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- 作者：Hideya Onishia ; ohnishi@surg1.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Akio Yamasakia ; Makoto Kawamotoa ; Akira Imaizumia ; b ; Mitsuo Katanoa
- 关键词：Hypoxia ; Hedgehog signaling ; Smoothened ; Mastermind-like 3 ; RBPJ ; Pancreatic cancer
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 February 2016
- 年：2016
- 卷：371
- 期：2
- 页码：143-150
- 全文大小：1898 K
文摘
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Expression of RBPJ and MAML3 increases under hypoxia but not normoxia conditions.
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RBPJ and MAML3 play important roles for hypoxia-induced upregulation of SMO.
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RBPJ and MAML3 contribute to the activation of Hedgehog signaling under hypoxia.
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RBPJ and MAML3 contribute to proliferation and invasiveness in pancreatic cancer.
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RBPJ and MAML3 could be therapeutic targets for pancreatic cancer.