TGF-β significantly regulates 213 proteins of the human fibroblast surface proteome.
PDGFRα expression and the number of positive cells is down-regulated by TGF-β.
TGF-β induces PDGF signaling by phosphorylation of Akt dependent on PDGFR expression.
Decreased PDGFRα levels correlate with increased expression of PDGFRβ, αSMA and collagen type V.