Npas4 deficiency increases vulnerability to juvenile stress in mice
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- 作者：Laurence Coutellier ; coutellier.8@osu.edu" class="auth_mail" title="E-mail the corresponding author ; Valerie Gilbert ; Ryan Shepard
- 关键词：Chronic stress ; Adolescence ; Npas4 ; Cognitive function ; Neuroblast
- 刊名：Behavioural Brain Research
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：295
- 期：Complete
- 页码：17-25
- 全文大小：1041 K
文摘
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Npas4 deficient mice show long-term cognitive deficits after exposure to juvenile chronic stress.
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Juvenile chronic stress induces long-lasting reduction of Npas4 expression in the prefrontal cortex.
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Juvenile chronic stress reduces the number of migrating neuroblasts toward cortical regions in Npas-deficient mice.