S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat

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• 作者：Rosi ; Susanna ; Giovannini ; Maria Grazia ; Lestage ; Pierre J. ; Mu&ntilde ; oz ; Carmen ; Corte ; Laura Della ; et. al.
• 关键词：Glutamate ; Microdialysis ; Passive avoidance test
• 刊名：Neuroscience Letters
• 出版年：2004
• 出版时间：May 6, 2004
• 年：2004
• 卷：361
• 期：1-3
• 页码：120-123
• 全文大小：154 K

文摘

The effect of S 18986, positive AMPA receptor modulator, on acetylcholine (ACh), gamma-aminobutyric acid (GABA) and glutamate (Glu) release from the hippocampus of freely moving young and aged rats was investigated by microdialysis coupled to HPLC. The cognition-enhancing properties were evaluated by a passive avoidance test. In 3 month-old rats, S 18986 (10 mg/kg i.p.) increased by 70 % ACh release, which returned to basal level within 2 h, while 3 mg/kg had no effect. In 22 month-old rats, both 3 and 10 mg/kg i.p. induced a long lasting increase in ACh release, as large as that induced by 10 mg/kg in young rats. S 18986 did not modify GABA and glutamate release. No effect on general behavior was observed, but S 18986 at both doses prevented the disrupting effect of scopolamine (1 mg/kg i.p.) on passive avoidance acquisition.