Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats
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- 作者：Kazuaki Kawaura1 ; Yukino Ogata1 ; Sokichi Honda ; Fumio Soeda ; Tetsuya Shirasaki ; Kazuo Takahama ; takahama@kumamoto-hsu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tipepidine ; Antitussive ; Treatment-resistant depression ; G protein-coupled inwardly rectifying potassium channel ; Dopamine
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：302
- 期：Complete
- 页码：269-278
- 全文大小：1754 K
文摘
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Tipepidine decreased the immobility in the forced swimming test in ACTH-treated rats.
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The effect of tipepidine was blocked by a catecholamine-depleting agent.
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The effect of tipepidine was blocked by a dopamine D1 receptor antagonist.
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The effect of tipepidine was blocked by an adrenaline α2 receptor antagonist.
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Tipepidine increased dopamine level of nucleus accumbens in ACTH-treated rats.