The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA

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• 作者：Jolanta Konieczny^a ; ^{koniecz@if-pan.krakow.pl} ; Anna Czarnecka^a ; ^&dagger ; ; Tomasz Lenda^a ; Kinga Kamińska^a ; Lucyna Antkiewicz-Michaluk^b
• 关键词：DA ; dopamine ; DOPAC ; dihydroxyphenylacetic acid ; HVA ; homovanilic acid ; MPP+ ; 1-methyl-4-phenylpyridinium ion ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; PD ; Parkinson&rsquo ; s disease ; SN ; substantia nigra ; SNc ; substantia nigra pars compacta ; SNr ; substantia nigra pars reticulata ; UPS ; ubiquitin&ndash ; proteasome system
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：308-318
• 全文大小：411 K
• 卷排序：340

文摘

Lactacystin and 6-OHDA produced similar declines in DA level in the striatum and SN. Both PD models did not differ in the intensity of amphetamine-induced rotations. Contralateral rotations after apomorphine were not observed in the lactacystin model. DA D2 receptor binding was increased in the lesioned striatum in both PD models. Striatal DA D1 receptor binding was increased bilaterally only following 6-OHDA.