Hypoallergenic hydrolysates of egg white proteins modulate allergen responses induced ex vivo on spleen cells from sensitized mice
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- 作者：Daniel Lozano-Ojalvo ; Elena Molina ; Rosina Ló ; pez-Fandiñ ; o ; rosina.lopez@csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：AE-OP ; peptide fractions of the hydrolysate of OVA with pepsin separated by anion exchange FPLC ; CT ; cholera toxin ; EW ; egg white ; LA ; hydrolysate of LYS with alcalase ; LP ; hydrolysate of LYS with pepsin ; LYS ; lysozyme ; MA ; hydrolysate of OM with alcalase ; MP ; hydrolysate of OM with pepsin ; OA ; hydrolysate of OVA with alcalase ; OM ; ovomucoid ; OP ; hydrolysate of OVA with pepsin ; OVA ; ovalbumin ; PBMCs ; peripheral blood mononuclear cells ; PCA ; passive cutaneous anaphylaxis ; RP-OP ; peptide fractions
- 刊名：Food Research International
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：89
- 期：part_P1
- 页码：661-669
- 全文大小：1440 K
文摘
- istitem" id="list_l0005">
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id="p0005">The hydrolysate of ovalbumin with pepsin is hypoallergenic in vivo.
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id="p0010">It induces a lower Th2 activation of spleen cells of sensitized mice than ovalbumin.
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id="p0015">The hydrolysate can down-regulate the Th2 responses induced by egg allergens.
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id="p0020">The hydrolysate can enhance Th1 responses.
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id="p0025">It can find applications for the treatment of egg allergy.