Hypothermia in mouse is caused by adenosine A₁ and A₃ receptor agonists and AMP via three distinct mechanisms

详细信息    查看全文

• 作者：Jesse Lea Carlin^a ; Shalini Jain^b ; Elizabeth Gizewski^d ; Tina C. Wan^d ; Dilip K. Tosh^c ; Cuiying Xiao^a ; John A. Auchampach^d ; Kenneth A. Jacobson^c ; Oksana Gavrilova^b ; Marc L. Reitman^a ; ^{marc.reitman@nih.gov}
• 关键词：Hypothermia ; Adenosine ; A1AR ; A3AR ; AMP ; Torpor
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：114
• 期：Complete
• 页码：101-113
• 全文大小：4942 K
• 卷排序：114

文摘

Some commonly used A1AR agonists are not selective; they act at A3AR. A1AR, A3AR, and AMP are three distinct adenosine-related inducers of hypothermia. Neither A1AR nor A3AR is required for fasting-induced torpor. AMP can cause hypothermia via the brain, independent of A1AR and A3AR.