Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity

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• 作者：Michaela Prchal ; Andreas Pilz ; Olivia Simma ; Karen Lingnau ; Alex ; er von Gabain ; Birgit Strobl ; Mathias M&#xfc ; ller ; Thomas Decker
• 关键词：Interferon ; Immune adjuvant ; T lymphocyte ; Dendritic cell
• 刊名：Vaccine
• 出版年：2009
• 出版时间：30 December 2009
• 年：2009
• 卷：27
• 期：Supplement 6
• 页码：G17-G20
• 全文大小：222 K

文摘

Originally identified as antiviral substances produced by infected cells, type I interferons (IFN-I) are now known to have a wide range of additional activities within both the innate and adaptive immune response. Here we review properties of IFN-I contributing to their ‘natural immune adjuvant’ character, and their important role for the function of complete Freund's adjuvant (CFA) and the TLR9-dependent immune adjuvant IC31. We show data to demonstrate that treatment with IFN-I boosts the ability of vaccine/adjuvant combinations to induce peptide-specific CTL in both young and old mice. We view these findings in the perspective of previous clinical applications of IFN-I for vaccination.