Nitric oxide delivery to cancer: Why and how?

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• 作者：Pierre Sonveaux ; B&#xe9 ; n&#xe9 ; dicte F. Jordan ; Bernard Gallez ; Olivier Feron
• 关键词：Nitric oxide ; Tumour vasculature ; Vasodilation ; Cell respiration ; Blood flow ; Tumour oxygenation ; Radiotherapy ; Chemotherapy ; Drug delivery ; Imaging
• 刊名：European Journal of Cancer
• 出版年：2009
• 出版时间：May 2009
• 年：2009
• 卷：45
• 期：8
• 页码：1352-1369
• 全文大小：600 K

文摘

Hypoxia and blood flow heterogeneities are characteristics of solid tumours and are major obstacles for therapy. Exploiting the biology of nitric oxide (NO), a small radical with multiple functions, is particularly attractive to circumvent these sources of resistance and to sensitise tumour to cytotoxic treatments such as radiotherapy and chemotherapy. Indeed, while NO mediates angiogenic effects, NO may also promote tumour perfusion, drug delivery and oxygenation. Different strategies to deliver NO to tumours and pertaining to the FECS-EJC award laureate’s work are reviewed, with a focus on their therapeutic potential. The development of techniques to monitor how and to which extent NO delivery influences the phenotype of a given tumour in a given patient is also discussed.