Nanoemulsions of olmesartan were prepared using spontaneous emulsification method by employing Box–Behnken design approach.
Prepared nanoemulsions showed reasonable particle size, polydispersity index, and showed potential skin permeation.
Optimized nanoemulsion showed enhanced bioavailability of olmesartan in Wistar rats.
In conclusion, transdermal delivery of olmesartan was substantially enhanced by selected nanoemulsions.