Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology

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• 作者：Zenab Attari^a ; ¹ ; Amita Bhandari^a ; ² ; P.C. Jagadish^b ; ³ ; Shaila Lewis^a ; ⁴ ; ^{s.lewis@manipal.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：OLM ; olmesartan medoxomil ; P407 ; Poloxamer 407 ; HPH ; high pressure homogenization ; PDI ; polydispersity index
• 刊名：Journal of the Saudi Pharmaceutical Society
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：24
• 期：1
• 页码：57-63
• 全文大小：1920 K

文摘

The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartan medoxomil (OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro intestinal absorption of OLM nanosuspension and plain OLM was studied using non-everted rat intestinal sac model. Optimal OLM nanosuspension was prepared by a combination of ball milling and probe sonication using stabilizer, Poloxamer 407. The formula exhibited particle size of 469.9 nm and zeta potential of −19.1 mV, which was subjected to ex vivo studies. The flux and apparent permeability coefficient in intestine from OLM nanosuspension was higher than the plain drug, thereby suggesting better drug delivery.