Comparative biodistribution and safety profiling of olmesartan medoxomil oil-in-water oral nanoemulsion

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• 作者：Bapi Gorain^a ; ^b ; ^{bapi@lincoln.edu.my} ; ^{bapi.gn@gmail.com} ; Hira Choudhury^a ; ^c ; Rakesh Kumar Tekade^d ; Saumen Karan^e ; P. Jaisankar^f ; Tapan Kumar Pal^a ; ^{proftkpal@gmail.com}
• 关键词：Olmesartan nanoemulsion ; Tissue distribution ; Sub-chronic toxicity ; Hematological parameters ; Histopathological characteristics ; Brain penetration
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：82
• 期：Complete
• 页码：20-31
• 全文大小：2333 K
• 卷排序：82

文摘

The 28-day toxicity study of the nanoemulsion proved to be a safe media to deliver olmesartan. Improved penetration of olmesartan through BBB following oral nanoemulsion delivery. The developed nano-delivery pose higher potential to step towards its clinical application. Olmesartan nanoemulsion can be explored in memory dysfunction and brain ischemia.