Bone turnover markers in patients with osteogenesis imperfecta
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- 作者：Braga ; Vania ; Gatti ; Davide ; Rossini ; Maurizio ; Colapietro ; Francesca ; Battaglia ; Elia ; Viapiana ; Ombretta ; et. al.
- 关键词：Osteogenesis imperfecta ; Markers of bone turnover ; Phosphatase alkaline ; Osteocalcin ; Type I collagen ; N-telopeptides ; Free-deoxypyridinoline
- 刊名：Bone
- 出版年：2004
- 出版时间：June, 2004
- 年：2004
- 卷：34
- 期：6
- 页码：1013-1016
- 全文大小：75.4 K
文摘
Osteogenesis imperfecta (OI) is a heterologous group of rare inherited bone disorders resulting from defect in collagen synthesis or function. In previous studies, bone turnover has been found either increased or low-normal. These contradictory results might result from the study population made of children with prior recent fractures. We measured serum total and bone alkaline phosphatase (total and bone AP) serum osteocalcin (sOC), serum type I collagen C-telopeptide breakdown products (sCTX), urinary free-deoxypyridinoline (ufDPD), and urinary cross-linked N-telopeptides of type I collagen (uNTX) in 39 male and 38 premenopausal patients with different types of OI aged between 18 and 51 years who had not experienced new clinical fracture during 12 months preceding the laboratory assessment. The study also includes a control group of 29 men and 26 women matched for age and gender.