COMTval158met polymorphism is associated with behavioral response and physiologic reactivity to socio-emotional stress in 4-month-old infants
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- 作者：Rosario Montirossoa ; rosario.montirosso@bp.lnf.it" class="auth_mail" title="E-mail the corresponding author ; Livio Provenzia ; Daniela Tavianb ; Sara Missagliab ; Maria Elisabetta Raggic ; Renato Borgattid
- 关键词：HPA axis ; Hypothalamic-Pituitary-Adrenal axis ; COMT ; catechol-O-methyltransferase (enzyme) ; COMTval158met ; polymorphism of COMT gene ; involving val-to-met substitution at codon 158 ; Met-carriers ; infants with a met-val or met&ndash ; met genotype of COMTval158met polymorphism ; Val-homozygotes ; infants with a val&ndash ; val genotype of COMTval158met polymorphism
- 刊名：Infant Behavior and Development
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：45
- 期：part_PA
- 页码：71-82
- 全文大小：788 K
文摘
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Infants differ in HPA axis response to stress (i.e., increasers vs. decreasers).
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COMTval158met polymorphism affects stress response, but no data exist on infants.
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Infants were exposed twice to a double-exposure Still-Face procedure.
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Met-carrier infants had higher negative emotionality to repeated stress exposure.
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Among increasers, met-carriers had higher cortisol response than val-homozygotes.