O-linked-N-acetylglucosamine transferase is associated with metastatic spread of human papillomavirus E6 and E7 oncoproteins to the lungs of mice

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• 作者：Sung Hwan Kim^a ; ¹ ; Yoon Sook Kim^b ; ¹ ; Mee Young Choi^b ; Minjun Kim^b ; Jun Ho Yang^a ; Hyun Oh Park^a ; In Seok Jang^a ; Sung Ho Moon^a ; Hyun Ok Kim^c ; Dae Hyun Song^d ; Dong Hoon Lee^b ; Gu Seob Roh^b ; Hyun Joon Kim^b ; Sang Soo Kang^b ; Gyeong Jae Cho^b ; Jun Young Choi^a ; ² ; Wan Sung Choi^b ; ² ; ^{choiws@gnu.ac.kr}
• 关键词：CXCR4 ; E6 ; E7 ; HPV-positive lung cancer ; Metastasis ; OGT
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：483
• 期：2
• 页码：793-802
• 全文大小：3248 K
• 卷排序：483

文摘

OGT increases E6/E7 in HeLa cells and mouse xenograft models, promoting tumor growth. OGT increases levels of HCF-1 in the lungs of tumor xenografts. OGT increases levels of CXCR4 in HeLa cells and the lungs of tumor xenografts.