Adiponectin limits monocytic microparticle-induced endothelial activation by modulation of the AMPK, Akt and NFκB signaling pathways
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- 作者：Mehroz Ehsana ; d ; ehsanm@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Krishna K. Singha ; b ; f ; singhk@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Fina Lovrena ; lovren@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Yi Pana ; pany@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Adrian Quana ; quana@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Laura-Eve Mantellaa ; e ; MantellaLa@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Paul Sandhua ; paul.singh.sandhu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hwee Teoha ; c ; teohh@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Mohammed Al-Omranb ; f ; alomranm@smh.ca" class="auth_mail" title="E-mail the corresponding author ; Subodh Vermaa ; d ; e ; f ; vermasu@smh.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adiponectin ; AMPK ; Endothelial cell ; Monocyte ; Microparticles ; NFκB
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：1-11
- 全文大小：1970 K
文摘
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Adiponectin limited the release of MPs from LPS-treated monocytes.
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Adiponectin attenuated LPS-induced MP expression of NLRP3 inflammasome.
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Adiponectin reduced mono-MP-evoked VCAM-1 expression and leukocyte-EC adhesion.
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Adiponectin regulates MP release in part via the AMPK, Akt and NFκB pathways.