The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain

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• 作者：Satoshi Toyama¹ ; ^{s-toyama@suite.plala.or.jp} ; Naohito Shimoyama² ; ^{nshimoya@jikei.ac.jp} ; Megumi Shimoyama ; ² ; ^{mshimoy@jikei.ac.jp}
• 关键词：Orexin ; Oxaliplatin ; Neuropathic pain
• 刊名：Neuropeptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：95-100
• 全文大小：590 K
• 卷排序：61

文摘

Orexin-A completely alleviated chemotherapy-induced mechanical allodynia in mice. The analgesic effect of orexin-A was mediated via orexin-1 receptors. Orexin receptor agonists may have therapeutic roles in chemotherapy-induced pain.