Decrease of delta oscillatory responses is associated with increased age in healthy elderly

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• 作者：Derya Durusu Emek-Savaş^a ; ^b ; ^c ; Bahar Gü ; ntekin^c ; Gö ; rsev G. Yener^b ; ^c ; ^d ; ^e ; Erol Başar^c ; ^{e.basar@iku.edu.tr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：P300 ; Event-related oscillations ; Delta ; Aging ; Healthy elderly
• 刊名：International Journal of Psychophysiology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：103
• 期：Complete
• 页码：103-109
• 全文大小：675 K

文摘

The purpose of this study was to investigate changes in delta event-related oscillations (EROs) in younger and older healthy elderly subjects. We hypothesized that delta EROs were affected by age-related changes, which could be reflected in a visual oddball paradigm.

Method

The study included two groups of subjects, 17 younger healthy elderly (mean age: 63.1 ± 2.8 years) and 17 gender- and education-matched older healthy elderly (mean age: 79.6 ± 5.2 years), who performed a visual oddball paradigm. EEG was recorded from F₃, F_z, F₄, C₃, C_z, C₄, P₃, P_z, P₄, O₁, O_z and O₂ locations. Peak-to-peak amplitudes of delta (0.5–3 Hz) target ERO responses during the post-stimulus 0–800 ms time window were measured. Repeated measures of ANOVA was used to analyze four locations (frontal, central, parietal, occipital), at three sagittal (left, midline, right) sites. Independent t-tests were applied for post-hoc analyses.

Results

The older healthy elderly group had 16–25% lower values for the maximum peak-to-peak amplitudes of delta ERO compared with the younger healthy elderly group over frontal (p < 0.003), central (p < 0.0001) and parietal (p < 0.007) locations [F_3.96 = 4.396, p = 0.015]. Furthermore, there was a moderate negative correlation between age and C_z peak-to-peak amplitude of target delta responses [r = − 0.401, p < 0.02], indicating the notion that peak-to-peak amplitude of C_z decreases as age increases.

Conclusion

In the present study younger healthy elderly showed significantly higher event-related delta responses than older healthy elderly at frontal, central and parietal locations. Moreover, delta ERO responses decreased in accordance with age.