Single-dose pharmacokinetics of vancomycin in porcine cancellous and cortical bone determined by microdialysis
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- 作者：Mats Buea ; b ; matsbue@clin.au.dk" class="auth_mail" title="E-mail the corresponding author ; Hanne Birke-Sø ; rensenb ; Theis M. Thillemannb ; c ; Tore F. Hardleid ; Kjeld Sø ; balleb ; c ; Mikkel Tø ; ttrupa ; b
- 关键词：Vancomycin ; Microdialysis ; Pharmacokinetics ; Bone ; Tissue penetration
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：46
- 期：4
- 页码：434-438
- 全文大小：477 K
文摘
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We explored the pharmacokinetics of vancomycin in porcine bone using microdialysis.
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A significant delayed and impaired penetration from plasma to bone was found.
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Cancellous and cortical bone may not be considered as one compartment.