Viscosupplementation for treating knee osteoarthrosis: review of the literature

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• 作者：Tiago Youssef Ammar ; Tomas Araujo Prado Pereira ; Saulo Luí ; s Lopes Mistura ; André ; Kuhn ; José ; Idilio Saggin ; Osmar Valadã ; o Lopes Jú ; nior ; ^{ovlopesjr@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; ^{brscjp.iotrs@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Knee ; Osteoarthritis ; Hyaluronic acid ; Viscosupplementation
• 刊名：Revista Brasileira de Ortopedia (English Edition)
• 出版年：2015
• 出版时间：September-October 2015
• 年：2015
• 卷：50
• 期：5
• 页码：489-494
• 全文大小：610 K

文摘

The aim here was to evaluate the evidence that might support or refute the use of intra-articular viscosupplementation in treating patients with symptomatic knee osteoarthrosis. A review of the literature was conducted using the Medline, PubMed and Cochrane Controlled Trial Register databases and Cochrane database systematic reviews (Cochrane Library). Only studies presenting a high level of evidence were taken into consideration. This study included analysis on randomized clinical trials that included at least 100 patients in each intervention group, meta-analyses and systematic reviews. Two meta-analyses, five systematic reviews and six randomized clinical trials fulfilled the inclusion criteria for this review. In the light of the best evidence available so far, there is no consensus for indicating or even for contraindicating the use of intra-articular viscosupplementation among patients with symptomatic knee osteoarthrosis (level of evidence I and degree of recommendation A). Further studies with appropriate methodology are needed to elucidate this matter.