Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host
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- 作者：Anna Schurich1 ; a.schurich@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Laura J. Pallett1 ; Danyal Jajbhay1 ; Jessica Wijngaarden1 ; Itziar Otano1 ; Upkar S. Gill2 ; Navjyot Hansi2 ; Patrick T. Kennedy2 ; Eleni Nastouli3 ; 4 ; Richard Gilson5 ; Christian Frezza6 ; Sian M. Henson7 ; Mala K. Maini1
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 August 2016
- 年：2016
- 卷：16
- 期：5
- 页码：1243-1252
- 全文大小：1703 K
文摘
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Exhausted CD8 T cells show increased expression of glucose transporter-1
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Functional, but not exhausted, T cells can use OXPHOS to supplement their energy demand
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Exhausted T cells harbor dysfunctional depolarized mitochondria
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Interleukin-12 can rescue mitochondrial function and effector responses in exhausted CD8