Structure and antimicrobial activity of platypus 鈥榠ntermediate鈥?defensin-like peptide
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- 作者：Allan M. Torresa ; a.torres@uws.edu.au" class="auth_mail ; Paramjit Bansalb ; Jennifer M.S. Kohc ; Guilhem Pagè ; sd ; Ming J. Wua ; Philip W. Kuchele
- 关键词：DLP ; defensin like-peptide ; Int-DLP ; intermediate defensin-like peptide ; Int-DLPa ; intermediate defensin-like peptide analogue ; OvCNP ; Ornithorhyncus venom C-type natriuretic peptide ; DQF-COSY ; double-quantum filtered correlation spectroscopy ; NOESY ; nuclear Overhauser enhancement spectroscopy ; TOCSY ; total correlation spectroscopy ; RMSD ; root mean square deviation
- 刊名：FEBS Letters
- 出版年：2 May 2014
- 年：2014
- 卷：588
- 期：9
- 页码：1821-1826
- 全文大小：863 K
文摘
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Three-dimensional structure and antimicrobial activity of Int-DLP were investigated.
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Structural fold of Int-DLP was similar to that of the DLPs and 尾-defensins.
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Int-DLP was potent against S. aureus and P. aeruginosa bacteria.
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The 4 arginine residues at the N-terminus are important for its antimicrobial potency.