Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase
详细信息 查看全文
- 作者：Xingsheng Lia ; John Knighta ; Sonia Farguea ; Brianna Buchalskia ; Zhengrong Guanb ; Edward W. Inschob ; Abigail Liebowc ; Kevin Fitzgeraldc ; William Querbesc ; W. Todd Lowtherd ; Ross P. Holmesa ; rholmes@uab.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1862
- 期：2
- 页码：233-239
- 全文大小：612 K
文摘
- •
Hydroxyproline metabolism in mice contributes significantly to oxalate synthesis.
- •
The contribution is greater in Agxt and Grhpr KO mice than in wild type mice.
- •
Decreasing hepatic GO and HYPDH expression decreases oxalate excretion.
- •
RNAi therapeutics could be helpful in treating Primary Hyperoxaluria.