Sulfation pattern of fucose branches affects the anti-hyperlipidemic activities of fucosylated chondroitin sulfate
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- 作者：Nian Wu1 ; Yu Zhang1 ; Xingqian Ye ; Yaqin Hu ; Tian Ding ; Shiguo Chen ; chenshiguo210@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AI ; atherosderosis index ; CSE ; standard chondroitin sulfate E ; fCS ; fucosylated chondroitin sulfate ; fCS-Ib ; fucosylated chondroitin sulfate from Isostichopus badionotus ; fCS-Pg ; fucosylated chondroitin sulfate from Pearsonothuria graeffei ; Fuc ; fucose ; GlcA ; glucuronic acid ; GalNAc ; N-acetylgalactosamine ; GOT ; glutamic-oxaloacetic transaminase ; HDL ; high density lipoprotein ; HDL-C ; high density lipoprotein cholesterol ; HPLC ; high performance liquid chromatography ; LDL ; low density lipoprotein
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 August 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：1-7
- 全文大小：970 K
文摘
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Two fCSs with well-repeated units but minor difference in sulfation pattern were investigated.
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Both fCS-Ib and fCS-Pg could significantly improve the lipid profile of HFFD mice.
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fCS-Pg was more effective in lowering blood TC, LDL and AI levels.
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Both fCSs obviously lowered serum glucose and increased hepatic glycogen synthesis.
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Both fCSs might be potential antihyperlipdemic drugs with liver protection effect.