Exposure of airway epithelial cells to Pseudomonas aeruginosa biofilm-derived quorum sensing molecules decrease the activity of the anti-oxidant response element bound by NRF2

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• 作者：Lucie Roussel ; Simon Rousseau ; ^{simon.rousseau@mcgill.ca}
• 关键词：p38 MAPK ; Cystic fibrosis ; Oxidant ; Infection ; CFTR ; Transcription
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：483
• 期：2
• 页码：829-833
• 全文大小：592 K
• 卷排序：483

文摘

Biofilm-derived exoproducts decrease the anti-oxidant response element activity. N-acyl-homoserine lactone lowers the activity of the anti-oxidant response element. Biofilm-derived material decreases the basal expression of HO-1 and NQO-1. CFTRdelF508 expression lowers the basal activity of the anti-oxidant response element.